The Cleveland Guardians retake the diamond tomorrow, Tuesday, July 21, 2026 for their second game against the Minnesota Twins.

First pitch is scheduled for 6:40 p.m.

EST airing on MLB.TV.

Parker Messick (8-5, 2.73) gets the start on the mound in this matchup with the Twins starting Bailey Ober (7-3, 4.32).

Williams’ last start came last Friday against the Miami Marlins where he pitched six innings surrendering one run and striking out just one batter in a winning effort.

The Guardians were active at the plate in the first game of the series and will look to continue their momentum on Tuesday night.

This could be a pivotal matchup, as the team is fighting to regain the lead in the AL Central standings.

Following the latest injury updates, the Guardians will be missing Angel Martines (foot) while the Twins appear to be at full health.

As a result, the data analysts at Dimers released their Guardians-Twins score prediction after conducting new simulations that took into account every element of matchup data.

The results of Dimers’ simulations were compared to updated sportsbook odds to compile the data-driven Twins vs.

Guardians preview below.

Guardians vs.

Twins betting preview Explore the interactive widget below to discover the current spread, over/under, and moneyline betting odds and probabilities for the Twins-Guardians matchup at Progressive Field.

This prediction and best bet for Tuesday’s MLB matchup between the Guardians and Twins is from Dimers.com, a dependable source for sports betting predictions.

Check out all the important details on tonight’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details Key information on the Twins-Guardians matchup, including where the game is and what time it tips off.

Teams: Cleveland Guardians vs.

Minnesota TwinsDate: Tuesday, July 21, 2026Time: 6:40 p.m.

ETLocation: Progressive Field (Cleveland, Ohio)MLB injuries: Check the latest updates to the official NBA injury report MLB Tuesday Odds Polymarket is one of the best platforms to trade on ahead of tipoff.

Here is the currently outlook of key markets for the Guardians-Twins MLB Game.