Australia has taken an unassailable 2-0 lead in their ODI series against West Indies with a 90-run win in the second match at St Kitts' Warner Park.

New captain Sophie Molineux rested her recent back injury and watched on as veteran Beth Mooney (65 off 104 balls) top-scored for the visitors, who managed 7-269 after winning the toss.

Spinners Georgia Wareham (3-29) and Ash Gardner (3-34) were key with the ball as the hosts rued a collapse of 7-34 on the turning deck in reply.

West Indies were all out for 179 after 46 overs on Monday (AEDT).

Ninth on the ICC's ODI rankings, West Indies had looked up for the fight against the world No.1 Aussies, who fell to 4-82 in the 16th over of their innings.

Ashmini Munisar (2-45) notably struck twice in two balls to topple heavyweights Georgia Voll (23) and Ellyse Perry, out for only her third golden duck in 166 ODIs.

Mooney and stand-in captain Tahlia McGrath....